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This may also lessen the extent to which astrocytes participate in peripheral immune cell recruitment and inflammation (Mecha et al., 2013)

2 Materials and methods 2.1 Construction of a nonalcoholic fatty liver model Male C57 mice aged 8 weeks and weighing between 18 and 22 g were randomly allocated into two groups: 9 mice in the high-fat group and 8 in the control group

As with other glutathione peroxidases, GPx1 has a conserved catalytic tetrad composed of Sec or Cys, Gln, Trp, and Asn, where the Sec is surrounded by four arginines (R 57, 103, 184, 185

Al-Mubarak, B

Supplementary Table 2)

Considering that SELENOP is also involved in the defense against oxidative damage and had a q-value that was second (Welch t-test q = 0.08, log(FC) = 0.66) to GPx3 in this group comparisons using an untargeted approach, we sought to monitor peptides of both of these proteins by targeted LC-MS/MS (Supplementary Fig